Looking the best hangover remedy? The caffeine in Coke, which constricts the brain’s blood vessels, can also help curb a pounding headache, says Kevin Strang, Ph.D., a distinguished faculty associate at University of Wisconsin Madison who has been teaching a course on how alcohol affects the body for 18 years. Meanwhile, Mexican soda can deliver additional benefits: Unlike U.S. versions filled with high-fructose corn syrup, Coke from our neighbors to the south is sweetened with plain old sugar that raises your body’s glucose levels even more quickly than conventional sodas, Strang explains.

Some people may even have a genetic disposition for worse hangovers than others. Scientists have to rely on people’s self-reported hangover symptoms, which may vary between people and depend on day-to-day factors, and these are very difficult to control scientifically. The lack of research has left room for a wide range of myths to develop about the best ways to cure a hangover, most of which rely on anecdotal evidence. Businesses may also make claims about specific cures to sell their products, despite little or no scientific basis.

Hangovers begin after blood alcohol levels start to fall. In fact, according to some experts, the worst symptoms occur when levels reach zero. The key ingredient seems to be “drinking to intoxication”; how much you drank to get there is less important. In fact, several studies suggest that light and moderate drinkers are more vulnerable to getting a hangover than heavy drinkers. Yet there’s also seemingly contradictory research showing that people with a family history of alcoholism have worse hangovers. Researchers say some people may end up with drinking problems because they drink in an effort to relieve hangover symptoms. Read even more details on Hangover Remedy.

Try Taking Some of These Supplements. Though research is limited, some studies have found that certain supplements could ease hangover symptoms. Below are a few supplements that have been researched for their ability to reduce hangover symptoms: Red ginseng: One study found that supplementing with red ginseng reduced blood alcohol levels, as well as hangover severity. Prickly pear: Some evidence shows that this type of cactus could help treat hangovers. A 2004 study found that prickly pear extract decreased hangover symptoms and cut the risk of hangover severity in half. Ginger: One study found that combining ginger with brown sugar and tangerine extract improved several hangover symptoms, including nausea, vomiting and diarrhea.

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